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Release kinetics of catechins from chewing gum
Xinghao Yang1, Guangji Wang, Xiaotong Zhang
1Pharmaceutical Research Center, Nanjing Normal University, Nanjing 210097, People's Republic of China. yangxinh@jlonline.com
Journal of Pharmaceutical Sciences
|January 6, 2004
Summary
This study developed extended-release chewing gum using Eudragit coating for catechins. Higher Eudragit levels prolonged catechin release, suggesting chewing gum
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Catechins are bioactive compounds with therapeutic potential.
- Chewing gum offers a unique oral delivery route for sustained release.
Purpose of the Study:
- To develop and characterize extended-release chewing gum formulations for catechins.
- To investigate the impact of Eudragit coating on catechin release kinetics.
- To evaluate polyvinyl acetates' effect on release profiles.
Main Methods:
- Novel solid dispersion and hot-melt fluid bed coating techniques were employed.
- Varying Eudragit coating levels were applied to catechin granules.
- In vivo release profiles and dissolution data were analyzed using kinetic models (zero-order, first-order, Higuchi).
Main Results:
- Increased Eudragit coating levels significantly prolonged catechin release from chewing gum.
- The Higuchi equation best described the release kinetics, indicating a diffusion-controlled process.
- Polyvinyl acetates also influenced catechin release profiles.
Conclusions:
- Chewing gum is a viable and promising system for controlled-release drug delivery.
- Eudragit coating offers an effective strategy for modulating catechin release.
- Further research into polymer selection can optimize drug release characteristics.