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Synthesis and some central pharmacological properties of new
D Matosiuk1, T Tkaczyński, E Jagiełło-Wójtowicz
1Department of Chemical Technology of Drugs, Medical Academy, Lublin, Poland.
Polish Journal of Pharmacology and Pharmacy
|May 1, 1992
Abstract:
Six new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic ethyl esters bearing an aromatic substituent in position 1 or 2 were obtained. Pharmacological studies on the central action of these derivatives were carried out on mice and rats. The highest activity showed compounds 1 and 2 which produced analgesic effects in mice.