Related Experiment Videos
[Effect of antifolates and folates on the antineoplastic action of fluoropyrimidines]
1Zakład Farmakologii Akademii Medycznej, Lodzi.
Postepy Higieny I Medycyny Doswiadczalnej
|January 1, 1992
Abstract:
The influence of folate and antifolate on the cytostatic activity of fluoropyrimidines has been examined extensively. From all of present work, it is apparent that methotrexate can be synergistic or antagonistic in its interaction with 5-fluorouracil, depending on the sequence used and the metabolic machinery present in the target cell. The interaction between commonly administered 5-fluorouracil and leucovorin may enhance carcinostatic efficacy of 5-fluorouracil in patients with colon carcinoma.