Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrocortisone-induced convulsions.

Majed Odeh1, Alexandra Lavy, Edy Stermer

  • 1Department of Internal Medicine B, Bnai Zion Medical Center, Technion Faculty of Medicine, Israel Institute of Technology, Haifa, Israel. majed.odeh@b-zion.org.il

Journal of Toxicology. Clinical Toxicology
|January 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Strong Correlation Between Pleural Fluid and Serum C-Reactive Protein Levels Across a Spectrum of Pleural Effusions.

Journal of clinical medicine research·2026
Same author

Diagnostic Efficacy of C-Reactive Protein in Differentiating Various Causes of Exudative Pleural Effusion: Disease Research Should Not Be Exclusive to the Wealthy.

Advances in respiratory medicine·2025
Same author

Bivalvular Endocarditis Due to Polymicrobial Coinfection with <i>Enterococcus faecalis</i> and <i>Coxiella burnetii</i>: A Case Report and Review of the Literature.

Medicina (Kaunas, Lithuania)·2024
Same author

The diagnostic value of nasal microbiota and clinical parameters in a multi-parametric prediction model to differentiate bacterial versus viral infections in lower respiratory tract infections.

PloS one·2022
Same author

Role of C-Reactive Protein in Discrimination between Transudative and Exudative Pleural Effusions.

Diagnostics (Basel, Switzerland)·2021
Same author

Early Detection and Intervention for Patients with Delirium Admitted to the Department of Internal Medicine: Lessons from a Pilot Initiative.

Dementia and geriatric cognitive disorders extra·2021
Same journal

Ingestion of high-dose buprenorphine by a 4 year-old child.

Journal of toxicology. Clinical toxicology·2005
Same journal

A reassessment of topical organic phosphorus insecticide exposures and permanent paralysis.

Journal of toxicology. Clinical toxicology·2005
Same journal

Methamphetamine toxicity secondary to intravaginal body stuffing.

Journal of toxicology. Clinical toxicology·2005
Same journal

Duodenal perforation after ibuprofen overdose.

Journal of toxicology. Clinical toxicology·2005
Same journal

Delayed dystonia following pimozide overdose in a child.

Journal of toxicology. Clinical toxicology·2005
Same journal

Pattern of acute poisonings in Mashhad, Iran 1993-2000.

Journal of toxicology. Clinical toxicology·2005
See all related articles

Glucocorticoids like hydrocortisone can cause seizures indirectly through electrolyte issues or high blood pressure. Rarely, these steroids may directly harm the central nervous system (CNS), leading to convulsions.

Area of Science:

  • Neurology
  • Endocrinology
  • Gastroenterology

Background:

  • Glucocorticoids are commonly used to manage inflammatory conditions like Crohn's disease.
  • Potential adverse effects of glucocorticoids include electrolyte imbalances, hypertension, and hyperglycemia.
  • Central nervous system (CNS) toxicity is a rare but documented side effect.

Observation:

  • A 23-year-old patient with Crohn's disease experienced recurrent generalized convulsions.
  • The convulsions occurred on two separate occasions.
  • Both episodes were temporally associated with the administration of intravenous hydrocortisone.

Findings:

  • The patient's seizures were potentially linked to intravenous hydrocortisone administration.
  • This case highlights the possibility of direct CNS toxicity from glucocorticoids.

Related Experiment Videos

  • The underlying mechanism may involve direct neurotoxicity rather than indirect effects like electrolyte abnormalities.

    • Implications:

    • Clinicians should consider direct CNS toxicity when patients on glucocorticoids develop seizures.
    • Further investigation into the neurotoxic potential of glucocorticoids is warranted.
    • This case emphasizes the importance of monitoring for neurological adverse events during glucocorticoid therapy.