Immunoreactive prostaglandin G/H synthase content increases in ovine cotyledons during late gestation

In this study, using gel electrophoresis and Western blotting, we have demonstrated that the content of irPGHS in ovine placenta increases during late gestation prior to the onset of labour. This increase in PGHS tissue content may contribute to the corresponding increased production of prostaglandins by the ovine placenta during this period of pregnancy. Although the mechanism by which PGHS tissue content is elevated at this time remains to be established, one possibility which is currently being investigated in our laboratory is that increased PGHS content reflects an increased level of PGHS gene expression.