Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simulation of roller compaction using a laboratory scale compaction simulator.

Andrey V Zinchuk1, Matthew P Mullarney, Bruno C Hancock

  • 1Global Research and Development, Pharmaceutical Research and Development, Pfizer Inc., MS-8156-007, Eastern Point Road, Groton, CT 06340, USA. andrey_v_zinchuk@groton.pfizer.com

International Journal of Pharmaceutics
|January 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep Stage Classification During CPAP Therapy from CPAP-Airflow and Wearable Fingertip Signals.

Sensors (Basel, Switzerland)·2026
Same author

Predicting sleep state from continuous positive airway pressure flow in patients with obstructive sleep apnea.

Sleep medicine·2026
Same author

Automatic sleep staging from CPAP airflow using a dual fusion multi-period convolutional neural network.

Physiological measurement·2026
Same author

Quantifying the intrinsic effects of lubrication to predict the tensile strength of pharmaceutical formulations.

International journal of pharmaceutics·2025
Same author

Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.

American journal of respiratory and critical care medicine·2025
Same author

Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea.

The European respiratory journal·2024
Same journal

Artificial intelligence and CRISPR-based approaches for targeted delivery of bacteriophages.

International journal of pharmaceutics·2026
Same journal

A "three-in-one" nose-to-brain delivery strategy: intranasal vancomycin spray achieves simultaneous clearance of pneumococcal colonization, bacteremia, and meningitis.

International journal of pharmaceutics·2026
Same journal

10-Hydroxy-2-decenoic acid /matrine deep eutectic solvent encapsulated in hyalurosomes for enhanced transdermal delivery and antioxidant efficacy.

International journal of pharmaceutics·2026
Same journal

Dual-trigger hyaluronic acid nanoprodrug incorporating a 2-nitrobenzenesulfonyl linker for CD44-targeted and glutathione-responsive drug delivery.

International journal of pharmaceutics·2026
Same journal

Polymeric mixed micellar nanogel enhances dermal delivery and therapeutic efficacy of tofacitinib citrate.

International journal of pharmaceutics·2026
Same journal

Localized gold nanoparticles-mediated photothermal therapy for head and neck cancer: in vivo proof-of-concept.

International journal of pharmaceutics·2026
See all related articles

A novel simulation method for roller compaction was developed, accurately predicting ribbon properties like solid fraction and tensile strength. This simulation offers material and cost efficiencies for pharmaceutical development.

Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering

Background:

  • Roller compaction is a key process in pharmaceutical manufacturing for producing granules.
  • Accurate simulation of this process is crucial for efficient scale-up and development.
  • Current methods require significant material and resources.

Purpose of the Study:

  • To develop and validate a laboratory-scale simulation method for roller compaction.
  • To assess the predictability of ribbon properties using the simulation.
  • To establish potential scale-up and transfer factors for the process.

Main Methods:

  • Development of a laboratory-scale compaction simulator.
  • Evaluation using microcrystalline cellulose as a model material.
  • Analysis of key ribbon properties: solid fraction and tensile strength.

Related Experiment Videos

Main Results:

  • Simulated and real ribbons showed similar compression behavior and tensile strength at equivalent solid fractions.
  • The simulation accurately predicts the effects of critical parameters (roll speed, pressure, radius).
  • The method requires a fraction of the material used in conventional equipment.

Conclusions:

  • The developed simulation method reliably predicts roller compaction ribbon properties.
  • Constant ribbon solid fraction and tensile strength can serve as scale-up factors.
  • This approach enhances material efficiency and facilitates earlier tablet formulation development.