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Targeted photodynamic therapy via receptor mediated delivery systems
Wesley M Sharman1, Johan E van Lier, Cynthia M Allen
1Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, Université de Sherbrooke, Québec, Canada.
Advanced Drug Delivery Reviews
|January 7, 2004
Summary
Targeted photodynamic therapy (PDT) enhances treatment by exploiting cellular changes in diseased cells. This review explores photosensitizer (PS) bioconjugates designed to improve PDT efficacy through targeted delivery and localization.
Area of Science:
- Biomedical Engineering
- Oncology
- Photochemistry
Background:
- Targeted photodynamic therapy (PDT) aims to improve treatment specificity by focusing on diseased cells.
- While antibody-drug conjugates are common, other cellular targets offer potential for photosensitizer (PS) delivery.
- Diseased cells exhibit unique characteristics like altered receptor expression and membrane composition.
Purpose of the Study:
- To review various photosensitizer (PS) bioconjugates for targeted photodynamic therapy (PDT).
- To explore how exploiting cellular transformations can enhance PDT efficacy.
- To summarize the outcomes of utilizing different targeting strategies in PDT.
Main Methods:
- Review of literature on PS bioconjugates for targeted PDT.
- Analysis of strategies exploiting cellular alterations (receptor expression, lipids, proteins, microenvironment).
- Evaluation of methods to increase PS uptake and improve subcellular localization.
Main Results:
- Various PS bioconjugates have been developed utilizing altered cellular features for targeting.
- Strategies focus on enhancing PS uptake by target cells and optimizing subcellular localization.
- Different bioconjugation approaches show promise in improving PDT efficiency.
Conclusions:
- Exploiting cellular transformations in diseased cells offers a potent strategy for targeted PDT.
- Optimizing PS delivery and localization is crucial for enhancing PDT efficacy.
- Further research into PS bioconjugates holds significant potential for advancing PDT applications.