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Updated: Aug 29, 2026
Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD)
Published on: September 27, 2010
Determination of cortical language dominance using functional transcranial Doppler sonography in left-handers
Silvio Basic1, Sanja Hajnsek, Zdravka Poljakovic
1Department of Neurology, University Hospital Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia. silvio.basic@zd.tel.hr
Objective:
Verbal analytical functions are primarily related to the left hemisphere in right-handers, but there is yet no agreement about cortical language dominance in left-handers. Also, there are some contradictory reports about sex differences in cortical language lateralization. The aim of this study is to investigate cortical language dominance in left-handers and to explore gender influence on cortical language representation.
Methods:
We performed functional transcranial Doppler sonography (previous validated for determination of cerebral language lateralization) during a word generation task, measuring changes in mean cerebral blood flow velocity (BFVmean) in both middle cerebral arteries (MCA) in 150 healthy subjects (75 left-handers and 75 right-handers). In left-handers we observed significant increase BFVmean in right MCA in 58 (77.3%) subjects. Bilateral increase was observed in 11 (14.7%) subjects and increase in left MCA in 6 (8%) subjects. In right-handed group 93.3% subjects showed left cortical dominance, while 6.7% showed bilateral language representation.
Results:
Current results showed significant (P<0.0001) right hemispheric language dominance in healthy left-handed subjects.
Conclusions:
Our results showed significant difference in hemispheric dominance for verbal function between righthanders and lefthanders. Also there is statistically insignificant female gender tendency for bilateral hemispheric language representation in both handedness.
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Related Concept Videos
01:28Lateralization
01:05Cerebral Hemispheres
01:10Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...