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Hepatic blood flow measurement.

J L Nxumalo, M Teranaka, W G Schenk

    Archives of Surgery (Chicago, Ill. : 1960)
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    This study compared hepatic blood flow measurements in dogs during circulatory overload. The indocyanine green method overestimated flow compared to the electromagnetic method, suggesting limitations in unsteady states.

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    Area of Science:

    • Physiology
    • Cardiovascular Research
    • Hepatic Blood Flow Dynamics

    Background:

    • Accurate measurement of total hepatic blood flow is crucial for understanding liver function.
    • Existing research primarily focuses on steady circulatory states, with limited data on unsteady conditions like circulatory overload or underload.
    • Investigating discrepancies in measurement techniques during altered hemodynamics is essential for clinical and research applications.

    Purpose of the Study:

    • To compare the accuracy of the single injection indocyanine green method versus the electromagnetic flow method for measuring total hepatic blood flow.
    • To evaluate these methods in a canine model experiencing circulatory overload induced by dextran 40 infusion.
    • To identify potential discrepancies in hepatic blood flow measurements during unsteady circulatory states.

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    Main Methods:

    • Utilized a canine model to induce circulatory overload via dextran 40 infusion.
    • Measured total hepatic blood flow using two distinct techniques: single injection of indocyanine green (indirect method) and electromagnetic flowmetry (direct method).
    • Compared the measurements obtained from both methods under normal and overloaded circulatory conditions.

    Main Results:

    • A close correlation was observed between the indocyanine green and electromagnetic flow methods in normal dogs.
    • Following dextran 40 infusion, the indocyanine green method significantly overestimated total hepatic blood flow by 40% to 60% compared to the electromagnetic method.
    • The underlying reasons for this overestimation during dextran-induced circulatory overload remain unclear based on this study.

    Conclusions:

    • The single injection indocyanine green method may not accurately reflect total hepatic blood flow in conditions of circulatory overload.
    • The electromagnetic flow method serves as a reliable standard for hepatic blood flow measurement, even during induced hemodynamic changes.
    • Further research is required to elucidate the mechanisms behind the discrepancy observed with the indocyanine green method in unsteady circulatory states.