Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skin anergy and tuberculosis.

J Maher1, P Kelly, P Hughes

  • 1Peamount Hospital, Newcastle, Co. Dublin, Ireland.

Respiratory Medicine
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DOSET: dose optimization with simultaneous efficacy and toxicity evaluation, motivated by a first-in-human phase I CAR T lymphoma trial.

ESMO open·2026
Same author

The COVID-19 pandemic has negatively affected health behaviours in those with pre- heart failure.

Irish medical journal·2023
Same author

The association of adolescents' smoking with the physical activity levels of their friends.

Preventive medicine·2023
Same author

Closing the Osteoporotic-Fracture Care Gap for Frail Older Persons.

Irish medical journal·2022
Same author

Particulate matter in aerosols produced by two last generation electronic cigarettes: a comparison in a real-world environment.

Pulmonology·2021
Same author

EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity.

Blood·2020
Same journal

Prediction of therapeutic effect of antifibrotic therapy for idiopathic pulmonary fibrosis using quantitative CT texture analysis.

Respiratory medicine·2026
Same journal

Obesity and Early Sepsis-Associated Acute Respiratory Distress Syndrome: A Prospective Multicenter Study.

Respiratory medicine·2026
Same journal

Adults with Congenital Lung Malformations: A Descriptive Analysis of an Underexplored Population.

Respiratory medicine·2026
Same journal

Risk Factors and Microbiological Characteristics of Ventilator-Associated Pneumonia in a Tunisian Intensive Care Unit During the COVID-19 Pandemic.

Respiratory medicine·2026
Same journal

Impact of Therapeutic Hypothermia on Oxygen Demand and Respiratory Function in Post-Cardiac Arrest Patients: A Retrospective Cohort Study.

Respiratory medicine·2026
Same journal

The longitudinal decrease in exercise tolerance and disease progression in mild-to-moderate COPD.

Respiratory medicine·2026
See all related articles

Tuberculin skin anergy, a negative Mantoux response, affects 8% of tuberculosis patients. Anergic patients often present with more advanced disease and higher mortality, but anergy may be temporary with treatment.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pulmonology

Background:

  • Tuberculin skin anergy (negative Mantoux response) is observed in 8% of tuberculosis (TB) patients.
  • Understanding the characteristics and outcomes of anergic TB patients is crucial for effective disease management.

Purpose of the Study:

  • To compare clinical, radiological, and treatment outcomes between tuberculosis patients with and without tuberculin skin anergy.
  • To investigate the potential reversibility of tuberculin skin anergy during antituberculous chemotherapy.

Main Methods:

  • Retrospective comparison of 81 tuberculosis patients with skin anergy against a control group with skin reactivity.
  • Analysis of clinical symptoms, chest radiography findings, microbiological data, and mortality.
  • Repeat Mantoux testing after 3 months of treatment in a subset of anergic patients.

Related Experiment Videos

Main Results:

  • Anergic patients were older, had fewer symptoms, but exhibited more advanced, bilateral, and miliary disease on chest radiographs.
  • Pyrexia and elevated ESR were more common in anergic patients, who also had lower rates of culture negativity after 1 month of treatment.
  • Mortality was higher in the anergic group, primarily from non-tuberculous causes. 14 of 20 anergic patients converted to positive tuberculin status after treatment.

Conclusions:

  • Tuberculin skin anergy in tuberculosis is associated with more severe disease and poorer early treatment response.
  • Tuberculin skin anergy may be a transient phenomenon, potentially reversible with effective antituberculous chemotherapy.