Red blood cell-derived ATP as a regulator of skeletal muscle perfusion

Mary L Ellsworth1

  • 1Saint Louis University School of Medicine, Saint Louis, MO 63104, USA. Ellsworthm@slu.edu

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Skeletal muscle fibers have the unique ability to switch between rest and contraction states, using different sources of ATP for energy. The contraction cycle and Ca2+ transport back into the sarcoplasmic reticulum for relaxation require significant ATP. However, the ATP reserves in muscle fibers are limited and can only sustain contractions for a few seconds. Additional ATP production becomes necessary for prolonged contractions. As a result, muscle fibers generate ATP through various sources,...
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Autoregulation of Blood Flow

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