[Effects of ozone therapy on the functional activity of the retina in patients with involutional central...

The retinal electrogenesis was studied in central chorioretinal dystrophy (CCRD) of different stages. The general peculiarities of the ozone-therapy influence on the functional retinal activity typical of any CCRD stage were detected; they comprise: an increasing activity of neurons in the muscular region and a specificity related with the dynamic functional activity of the retinal peripheral segments peculiar of each disease stage. A sharp growth of glial index Cg (b/R12) detected in all patients is indicative of an activated metabolism of Mueller glial cells and of impaired glial-neuron relations in the retina as observed in CCRD. A decreasing Cg, observed after ozone-therapy, is an indirect confirmation of anti-hypoxic effect produced by ozone, which can be regarded as a patho-physiological mechanism of its positive influence on the dynamics of the functional retinal activity. Ozone-therapy is recommended to be implemented with the electroretinography monitoring.