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Updated: Jul 31, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
[Synthesis of functionalized cyanines. Fluorescence properties following complexation of cations]
M R Mazières1, C Duprat, E Sutra
1Synthèse et Physicochimie de Molécules d'Intérêt Biologique-UMR 5068, Université Paul Sabatier 118, Route de Narbonne-F-31062 Toulouse, France. mrm@chimie.ups-tlse.fr
Abstract:
The ionophoric properties of podands containing dioxazaphosphocane moieties linked by inactive spacers were studied. To increase the detection sensibility of these compounds we introduced a cyanine as spacer. Fluorescence analysis demonstrated the interest of cyanines as active spacers since the complexation by cations as Ca2+ and Mg2+ gives an enhancement of the emission intensity.
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