Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-throughput nuclear magnetic resonance analysis using a multiple coil flow probe.

Megan A Macnaughtan1, Ting Hou, Jun Xu

  • 1Department of Chemistry, Purdue University, 560 Oval Drive,West Lafayette, Indiana 47907-2084, USA.

Analytical Chemistry
|January 8, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolome remodeling with reverse-engineered exclusive enteral nutrition in children with active Crohn's disease.

Inflammatory bowel diseases·2026
Same author

Metabolomic signatures of dietary carbohydrates and differential association with type 2 diabetes.

Nature health·2026
Same author

Plant-based whole-food diets are feasible during auto-HCT and are associated with dose-dependent microbiome modulation.

Blood advances·2026
Same author

ssNetShift: single-sample metabolic network rewiring reveals hidden prognostic subtypes beyond clinical staging in gastric cancer.

Briefings in bioinformatics·2026
Same author

Variable Selection with FDR Control for Noisy Data - An Application to Screening Metabolites that Are Associated with Breast Cancer and Colorectal Cancer.

Journal of data science : JDS·2026
Same author

Correction: What's in a name? Metabolite identification: challenges and pitfalls in untargeted metabolomics.

Metabolomics : Official journal of the Metabolomic Society·2026

A new automated nuclear magnetic resonance (NMR) method uses a Multiplex NMR probe for rapid analysis. This high-throughput technique significantly speeds up the detection of small samples, achieving analysis rates of 1 sample per 34 seconds.

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Biophysics

Background:

  • High-throughput screening is crucial for modern scientific research.
  • Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique.
  • Current NMR methods can be time-consuming for large sample sets.

Purpose of the Study:

  • To develop an automated, high-throughput method for NMR spectroscopy.
  • To enhance the analysis rate for small volume, mass-limited samples.
  • To enable rapid succession analysis of multiple samples.

Main Methods:

  • Development of a four-coil Multiplex NMR probe with solenoidal microcoils.
  • Optimization of the probe for small volume, mass-limited samples.
  • Implementation of a flow-through design with robotics liquid handling for simultaneous injection.

Related Experiment Videos

  • Utilization of selective excitation experiments for rapid analysis.

    • Main Results:

    • Achieved a high-throughput analysis rate of 1 sample/34 s for 1D 1H NMR.
    • Demonstrated simultaneous injection of four samples.
    • Reduced analysis time through rapid selective excitation.
    • Successfully applied the method to small volume, mass-limited samples.

    Conclusions:

    • The developed automated Multiplex NMR probe enables significantly faster sample analysis.
    • This method is highly effective for high-throughput screening of limited sample quantities.
    • The system offers a promising advancement for accelerating NMR-based research.