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Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
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Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Published on: March 12, 2015

Vaccination against congenital toxoplasmosis

Safeya M Ali1, Sonia R Allam, Azza Y Negm

  • 1Department of Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Journal of the Egyptian Society of Parasitology
|January 8, 2004
PubMed

Different types of Toxoplasma gondii vaccines were evaluated using parasitological and histopathological means to induce immunity in Swiss pregnant mice and their pups against the challenge with virulent RH strain. Immunization was performed before mating by using live cyst vaccines (LCV), LCV-IL-2 combination, irradiated cyst vaccine (ICV) and ICV-IL-2 combination. It was demonstrated that pre-immunization with the current vaccines offered significant protection of both dams and pups. The highest level of protection was noticed in mice which received LCV-IL-2, followed by ICV-IL-2, then LCV and the least protection was elicited in dams immunized with ICV alone. The results threw light on the possibility of applying such vaccines not only in mice but also in other mammalian hosts including human.

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