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Published on: April 17, 2026

Scedosporium species infections and treatments

W J Steinbach1, J R Perfect

  • 1Department of Pediatrics, Duke University, Durham, NC 27710, USA. stein022@mc.duke.edu

Journal of Chemotherapy (Florence, Italy)
|January 8, 2004
PubMed

Insights

Scedosporium species infections are challenging due to antifungal resistance, particularly in immunocompromised patients. This review covers diagnosis and treatment, highlighting newer antifungal therapies for these difficult-to-treat infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases

Background:

  • Scedosporium species are increasingly identified in patient infections.
  • These fungi often exhibit resistance to conventional antifungal drugs, notably amphotericin B.
  • Scedosporium prolificans presents particular challenges due to its limited susceptibility to existing treatments.

Purpose of the Study:

  • To provide a comprehensive overview of Scedosporium species infections.
  • To discuss the microbiology, epidemiology, clinical manifestations, and diagnostic approaches.
  • To review current and emerging therapeutic strategies for Scedosporium infections.

Main Methods:

  • Literature review of Scedosporium species.
  • Analysis of microbiological, epidemiological, and clinical data.
  • Evaluation of in vitro, animal model, and clinical treatment data.

Main Results:

  • Scedosporium infections are becoming more prevalent in diverse patient groups.
  • Established antifungal agents show limited efficacy against many Scedosporium species.
  • Emerging antifungal therapies show promise for managing these recalcitrant infections.

Conclusions:

  • Effective management of Scedosporium infections requires accurate diagnostics and tailored treatment.
  • Newer antifungal agents are crucial for addressing the resistance challenges posed by Scedosporium species.
  • Further research into novel therapies is warranted for Scedosporium infections.

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