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Postmenopausal hormone therapy and migraine headache.

Anastasia L Misakian1, Robert D Langer, Isabela M Bensenor

  • 1University of California-San Diego School of Medicine, San Diego, California, USA.

Journal of Women'S Health (2002)
|January 8, 2004
PubMed
Summary

Current hormone therapy (HT) use is linked to increased migraine headaches in postmenopausal women. This study suggests a connection, but further clinical trials are needed to confirm if HT causes migraines.

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Area of Science:

  • Neurology
  • Endocrinology
  • Epidemiology

Background:

  • Estrogen withdrawal is a known migraine trigger.
  • Hormone therapy (HT) may exacerbate migraines, but population-based data are lacking.
  • This study addresses the association between HT and migraine in postmenopausal women.

Purpose of the Study:

  • To investigate the relationship between hormone therapy (HT) use and migraine headaches.
  • To examine HT characteristics and their association with migraine in postmenopausal women.

Main Methods:

  • A cross-sectional study of 17,107 postmenopausal women from the Women's Health Study.
  • Self-reported data on HT use, HT characteristics, and migraine within the past year.
  • Statistical analysis adjusted for various demographic and lifestyle factors.

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Main Results:

  • 11.2% of women reported migraine headaches.
  • Current HT users had a 1.42 times higher odds of migraine compared to never users.
  • Both estrogen-only and combined estrogen-progestin HT users showed similar increased odds of migraine.

Conclusions:

  • Current hormone therapy use is associated with higher rates of migraine headaches in postmenopausal women.
  • Further clinical trials are necessary to establish causality.
  • The findings highlight a potential link between HT and migraine incidence.