Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Dose-Response Relationship: Selectivity and Specificity

Dose-Response Relationship: Selectivity and Specificity

Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...

Common Ion Effect

Common Ion Effect

Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:

Sensory Modalities

Sensory Modalities

Sensation typically is the process by which the sensory receptors and sense organs detect stimuli from the internal and external environment and transmit this information to the central nervous system for processing.
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...

Frequency-dependent Selection

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.

Common Respiratory Disorders

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...

What is Natural Selection?

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mitigating Recombination Losses in CZTSSe Solar Cells via Interface Engineering: A Comprehensive Review.

Molecules (Basel, Switzerland)·2026

Same author

Enhancing sheep rumen health with Przewalskia tangutica: boosting fermentation and microbial diversity in saline-alkali sown pastures.

Animal microbiome·2026

Same author

Music-selective cortex is sensitive to structure in both pitch and time.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same author

Electroacupuncture Alleviates Pain and Anxiety in CFA-Induced Mice by Suppressing Glutamatergic Neurons in the Spinoparabrachial Pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Same author

A peptide-based PROTAC targeting FOXM1 suppresses fibrosis-associated hepatocarcinogenesis.

Theranostics·2026

Same author

Deciphering the immunomodulatory code: how metal nanoadjuvants orchestrate intracellular immune signaling cascades.

Biochemical pharmacology·2026

Search research articles

Related Experiment Video

Updated: Jan 24, 2026

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Published on: September 22, 2014

Common neural substrates for response selection across modalities and mapping paradigms.

Yuhong Jiang¹, Nancy Kanwisher

¹Massachusetts Institute of Technology, USA. yuhong@wjh.harvard.edu

Journal of Cognitive Neuroscience

|January 8, 2004

Summary

Response selection, a central bottleneck in human processing, involves common brain regions across different sensory inputs and mapping rules. This finding supports a unified neural basis for this critical cognitive function.

More Related Videos

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

Cross-Modal Multivariate Pattern Analysis

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

Related Experiment Videos

Last Updated: Jan 24, 2026

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Published on: September 22, 2014

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

Cross-Modal Multivariate Pattern Analysis

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

Area of Science:

Cognitive Neuroscience
Human Information Processing
Neuroimaging

Background:

Behavioral studies suggest response selection is a central bottleneck.
The neural basis for this bottleneck across different tasks remains unclear.

Purpose of the Study:

To investigate common and distinct brain regions for response selection.
To examine response selection across visual, auditory, and verbal tasks.
To explore mapping rules across spatial and nonspatial domains.

Main Methods:

Functional magnetic resonance imaging (fMRI) was employed.
Three experiments tested visual-manual, auditory-manual, and verbal tasks.
Stimulus-response mapping complexity was manipulated (compatible vs. incompatible rules).

Main Results:

Extensive activation overlap was found in bilateral parietal and frontal regions.
Common neural substrates were identified for response selection.
This overlap occurred across different input modalities and mapping types.

Conclusions:

Response selection is a central process supported by common neural substrates.
Neural mechanisms for response selection are consistent across sensory inputs.
Findings align with behavioral evidence of a central processing bottleneck.