Related Experiment Video
Updated: Aug 29, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Evidence for a reversal with age in the pattern of near-wall blood flow around aortic branches
Sara L Al-Musawi1, James Bishton, Jennifer Dean
1School of Animal and Microbial Sciences, University of Reading, Whiteknights, P.O. Box 228, Reading, RG6 6AJ, UK.
Abstract:
The changes that occur with age in the distribution of atherosclerotic lesions around arterial branch points challenge accepted theories relating disease to haemodynamic stresses. We investigated whether flow near branch points changes with age in a way that can account for the different lesion distributions. Flow around 20 branches from immature and mature aortas was investigated by examining the length:width ratio and orientation of endothelial nuclei; these properties depend on the magnitude and direction of near-wall flows, respectively. There were significant changes in the pattern of nuclear shape with age, consistent with a reversal in the pattern of shear around branches. In control regions away from branches, there were no such changes. The role of haemodynamic stresses in atherogenesis may require re-evaluation in the light of these results.
More Related Videos
04:48Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
Published on: November 28, 2018
09:24O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
Published on: October 6, 2022
Related Concept Videos
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Aortic Regurgitation I: Introduction
Sites for measuring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
The Arch of Aorta
Encircling the heart, the coronary arteries form a ring-like structure before...