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Nasal/buccal midazolam use in the community
M T Wilson1, S Macleod, M E O'Regan
1Royal Hospital For Sick Children, Glasgow, UK. margaret.wilson@yorkhill.scot.nhs.uk
Archives of Disease in Childhood
|January 8, 2004
Summary
Nasal/buccal midazolam effectively and conveniently terminates prolonged seizures in the community. Most families preferred this method over rectal diazepam for seizure management.
Area of Science:
- Neurology
- Pharmacology
- Public Health
Background:
- Prolonged seizures pose a significant challenge in community settings.
- Existing treatments like rectal diazepam have limitations in administration and acceptance.
- Need for accessible and effective emergency seizure termination medications.
Purpose of the Study:
- To evaluate the effectiveness and convenience of nasal/buccal midazolam for prolonged seizures.
- To compare family preference for nasal/buccal midazolam versus rectal diazepam.
- To assess the real-world utility of midazolam in community-based seizure management.
Main Methods:
- Telephone survey conducted with families managing prolonged seizures.
- Data collected on the use, effectiveness, and ease of administration of nasal/buccal midazolam.
- Comparative preference data gathered between midazolam and rectal diazepam.
Main Results:
- 83% (33/40) of families reported nasal/buccal midazolam as effective and easy to use.
- 83% (20/24) of families preferred midazolam over rectal diazepam.
- High satisfaction rates indicate successful community implementation.
Conclusions:
- Nasal/buccal midazolam is a highly effective and convenient option for terminating prolonged seizures at home.
- Midazolam offers a preferred alternative to rectal diazepam for community seizure management.
- This delivery method shows promise for improving emergency care for epilepsy patients outside clinical settings.