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Angiogenesis inhibitors in clinical development; where are we now and where are we going?

F A L M Eskens1

  • 11Department of Medical Oncology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands. f.eskens@erasmusmc.nl

British Journal of Cancer
|January 8, 2004
PubMed

Insights

Angiogenesis inhibitors are safe but rarely cause tumor regression. Combining them with chemotherapy shows promise for enhanced anticancer activity and future combination therapies.

Area of Science:

  • Oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Angiogenesis is vital for tumor growth and metastasis.
  • Multiple classes of angiogenesis inhibitors target distinct steps in this process.

Purpose of the Study:

  • To summarize clinical study results of angiogenesis inhibitors.
  • To evaluate their safety, efficacy, and potential combinations.

Main Methods:

  • Review of clinical studies involving angiogenesis inhibitors.
  • Analysis of safety profiles and tumor response data.
  • Assessment of combination strategies with chemotherapy.

Main Results:

  • Angiogenesis inhibitors are generally safe but rarely induce tumor regression.
  • Combination with cytotoxic chemotherapy can improve anticancer effects.
  • Promising clinical efficacy data have recently emerged.

Conclusions:

  • While safe, current angiogenesis inhibitors show limited tumor regression.
  • Combining different classes of inhibitors may enhance antiangiogenic and anticancer activity.
  • Development of validated biomarkers for biological activity is crucial for future studies.

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