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Updated: Aug 29, 2026

Solid Plate-based Dietary Restriction in Caenorhabditis elegans
Published on: May 28, 2011
Caloric restriction and insulin-like growth factors in aging and cancer
1Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA. sellc@mlhs.org
Abstract:
This review examines the influence of a reduction in caloric intake on cancer and longevity. Data indicating that rodents subjected to caloric restriction display lower tumor incidence, reduced susceptibility to carcinogens and extended lifespan is analyzed. The potential role of the growth hormone/insulin-like growth factor type 1 (IGF-I) axis in this effect is discussed as is the evidence that a reduction in growth hormone and/or IGF-I leads to a reduction in spontaneous tumors and susceptibility to carcinogens.
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