Related Experiment Video
Updated: Jul 21, 2026

MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium
Published on: June 24, 2014
Subcellular localization of IRS-1 in cell proliferation and differentiation
X Tu1, A Wu, A Maiorana
1Kimmel Cancer Center, Thomas Jefferson University, Philadelphia 19107, USA.
Abstract:
The type 1 insulin-like growth factor receptor (IGF-IR) and its docking protein, insulin receptor substrate-1 (IRS-1), play important roles in cell transformation, cell differentiation and aging. IRS-1 and other IRS proteins can, under certain conditions, localize to the nuclei of cells, where they undergo interactions with nuclear and nucleolar proteins. In this study, we confirm and extend these observations, demonstrating that IRS-1 is preferentially nuclear in growing cells. Differentiation and inhibition of ribosomal RNA synthesis cause subcellular redistribution of IRS-1 and other nuclear proteins to the cytoplasm.
Related Concept Videos
Cells Coordinate Growth and Proliferation
Distribution of Cytoplasmic Content
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Regulation of the Unfolded Protein Response
Cells Coordinate Growth and Proliferation
Renewal of Intestinal Stem Cells
iPS Cell Differentiation

