Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone microdamage and cell apoptosis.

B Noble1

  • 1Musculo-Skeletal Research Unit, University of Edinburgh Medical School, Edinburgh, Scotland, UK. Brendon.Noble@ed.ac.uk

European Cells & Materials
|January 8, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can comprehensive specialised end-of-life care be provided at home? Lessons from a study of an innovative consultant-led community service in the UK.

European journal of cancer care·2014
Same author

Techniques for promoting a healthier society: Thoughts on prevention planning and needs assessment.

The journal of primary prevention·2013
Same author

Blunting of adaptive responses to resistance exercise training in women over 75y.

Experimental gerontology·2011
Same author

Differential responses of human tumor-cells to polyunsaturated Fatty-acids - stimulation of proliferation of a colon-tumor cell-line by docosahexaenoic Acid.

International journal of oncology·2011
Same author

End-of-life decisions in the United Kingdom involving medical practitioners and legalisation of euthanasia or physician-assisted suicide: survey of doctors' attitudes.

Palliative medicine·2009
Same author

Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial.

Leukemia·2009

Bone microdamage accumulation weakens the skeleton. Osteocyte apoptosis may signal targeted bone repair, a mechanism crucial for maintaining skeletal integrity in aging and disease.

Area of Science:

  • Bone biology
  • Skeletal biomechanics
  • Cellular signaling

Background:

  • Bone microdamage accumulation compromises skeletal strength.
  • Healthy bone self-repairs by sensing and replacing damaged areas.
  • Reduced repair capacity is observed in aging and disease.

Purpose of the Study:

  • Investigate the mechanism of targeted bone repair.
  • Explore the role of osteocytes in sensing and signaling bone damage.
  • Examine the potential involvement of osteocyte apoptosis in initiating repair.

Main Methods:

  • Review of existing data on osteocyte function and microdamage.
  • Analysis of evidence supporting or refuting osteocyte apoptosis as a damage signal.
  • Consideration of molecular mechanisms in bone and other tissues.

Related Experiment Videos

Main Results:

  • Osteocytes, abundant in bone matrix, are hypothesized to sense microdamage.
  • Evidence suggests osteocyte function may be altered near microcracks.
  • Osteocyte apoptotic cell death is proposed as a potential signal for targeted bone removal and repair.

Conclusions:

  • Osteocyte apoptosis may be a key signal for targeted bone repair.
  • Understanding this mechanism is crucial for addressing age-related bone loss and disease.
  • Further research into molecular pathways is warranted to elucidate controlled cell death's role in skeletal repair.