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Updated: Aug 12, 2026
Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Isolated gingival metastasis from hepatocellular carcinoma mimicking a pyogenic granuloma
José Ramón Ramirez1, Juan Seoane, Juan Montero
1Pathology Service, "Gomez-Ulla" University Military Hospital, Madrid, Spain. mromerome@nexo.es
Background:
Oral metastatic tumours are uncommon and account for approximately 1% of malignant oral neoplasms.
Results:
If the cases where the oral location is in the jawbone, with secondary invasion to the oral soft tissue, are excluded, only 10 cases of gingival metastasis from hepatocellular carcinoma (HCC) have been previously reported in the literature. The clinicopathologic features of an HCC with gingival metastasis are reported. Six months after the multicentric HCC and alcoholic cirrhosis was diagnosed, a 65-year-old male patient presented a rapidly growing, lobulated and reddish exophytic lesion that was located in the gum in the incisal region of the upper jaw. The lesion was excised, and the final diagnosis of gingival metastasis of the HCC was established. Diagnostic investigations did not show any evidence of other metastatic lesions. This article describes a case with solitary metastasis from HCC in the gingiva, an event that, to our knowledge, has not been previously published.
Conclusions:
The clinical appearance of isolated gingival metastasis from HCC in the present case mimicked a pyogenic granuloma.
