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Updated: Aug 29, 2026

Murine Kidney Transplant Technique
Published on: October 20, 2015
Current status of kidney transplant: update 2003
1Division of Pediatric Nephrology, University of Alabama at Birmingham, 1600 7th Avenue S-ACC 516, Birmingham, AL 35233, USA. mbenfield@peds.uab.edu
Insights
Pediatric transplantation has advanced significantly, improving survival rates and quality of life for young patients. Future research aims to reduce immunosuppression and achieve transplantation tolerance.
Area of Science:
- Pediatric transplantation
- Immunology
- Organ transplantation
Background:
- Pediatric transplantation has seen significant progress in the last 20 years.
- Improvements include reduced morbidity, mortality, and rejection rates.
- Enhanced long-term patient and allograft survival are key outcomes.
Purpose of the Study:
- To review the advancements in pediatric transplantation.
- To highlight the improved outcomes and quality of life.
- To discuss future directions in the field.
Main Methods:
- Review of recent literature on pediatric transplantation.
- Analysis of survival rates and complication data.
- Discussion of emerging trends and future possibilities.
Main Results:
- Infants show superior short-term survival rates.
- Short-term allograft survival in deceased donor (CD) recipients matches living donor (LD) recipients.
- Decreased rejection is leading to dramatically improved long-term allograft survival.
Conclusions:
- Pediatric transplantation offers reduced risks and improved patient well-being.
- Future opportunities include minimizing immunosuppression and achieving transplantation tolerance.
- The field holds exciting prospects for further advancements.
Abstract:
Pediatric transplantation has seen remarkable advances over the past two decades with reduced morbidity and mortality, reduced rejection rates, and improved long-term patient and allograft survival. Infants currently have short-term patient and allograft survival rates better than any other age group; short-term allograft survival rates in CD recipients are equal to those in LD recipients. With decreased rejection, long-term allograft survival is improving dramatically. Transplantation allows for much reduced risks and improved metabolic status, growth and development, and more normal social interactions. The future of transplantation continues to be exciting, with opportunities for reduced immunosuppressive medications and their side effects, and the elusive goal of transplantation tolerance seems within reach.
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