Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperhomocysteinemia masquerading as pulmonary embolism.

S I Dani1, S Thanvi, J M Shah

  • 1UN Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Ahmedabad 380016 (Gujarat).

The Journal of the Association of Physicians of India
|January 9, 2004
PubMed
Summary

A case study reveals vitamin B12 deficiency causing megaloblastic anemia and hyperhomocysteinemia, leading to deep vein thrombosis and pulmonary embolism. This rare association highlights a novel cause for recurrent venous thromboembolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transgenerational somatic mutations and epigenetic imprints on selected DNA repair gene promoters in Arabidopsis thaliana due to pesticides.

Plant biology (Stuttgart, Germany)·2026
Same author

Role of MALDI-TOF mass spectrometry and molecular typing methods in an outbreak investigation of Pseudomonas stutzeri acute endophthalmitis post-phacoemulsification.

The Journal of hospital infection·2023
Same author

Comment on Ecker et al., Techniques in Coloproctology 27:339-342, 2023.

Techniques in coloproctology·2023
Same author

The role of primary school composition in affective decision-making: a prospective cohort study.

Social psychiatry and psychiatric epidemiology·2022
Same author

Author Correction: Modulation of optical absorption in m-Fe<sub>1-x</sub>Ru<sub>x</sub>S<sub>2</sub> and exploring stability in new m-RuS<sub>2</sub>.

Scientific reports·2021
Same author

Modulation of optical absorption in m-Fe<sub>1-x</sub>Ru<sub>x</sub>S<sub>2</sub> and exploring stability in new m-RuS<sub>2</sub>.

Scientific reports·2021

Area of Science:

  • Cardiology
  • Hematology
  • Internal Medicine

Background:

  • Deep vein thrombosis (DVT) and pulmonary embolism (PE) are significant causes of morbidity and mortality.
  • Hyperhomocysteinemia is a known risk factor for venous thromboembolism.
  • Vitamin B12 deficiency can lead to megaloblastic anemia and elevated homocysteine levels.

Observation:

  • A 30-year-old male presented with acute symptoms suggestive of pulmonary embolism, including breathlessness and tachycardia.
  • Physical examination revealed jugular venous distension with clear lungs.
  • Diagnostic workup showed normal chest X-ray, ECG findings of right ventricular strain, and echocardiographic evidence of right heart strain and pulmonary hypertension.

Findings:

  • Doppler confirmed deep venous system thrombosis.

Related Experiment Videos

  • Routine investigations for DVT etiology were normal except for significantly elevated serum homocysteine.
  • Megaloblastic anemia and vitamin B12 deficiency were identified as the underlying cause of hyperhomocysteinemia.

    • Implications:

    • This case highlights a rare but significant association between vitamin B12 deficiency, hyperhomocysteinemia, and recurrent DVT/PE.
    • Early identification and management of vitamin B12 deficiency may prevent life-threatening thromboembolic events.
    • Clinicians should consider vitamin B12 deficiency in the etiology of unexplained hyperhomocysteinemia and recurrent venous thromboembolism.