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Updated: Aug 29, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
Published on: October 20, 2014
Roles of the semaphorin family in immune regulation
Atsushi Kumanogoh1, Hitoshi Kikutani
1Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Abstract:
The immune system and the nervous system have distinct roles in maintaining physiological homeostasis. These independent systems, however, influence each other while sharing common resources, including the cytokines and members of the immunoglobulin superfamily. Semaphorins are one of these shared molecular families that are biologically active in both systems. Although semaphorins were originally identified as axon guidance factors functioning in the nervous system, recent studies have uncovered additional immunological functions. For example, ligand-receptor systems distinct from those characterized in the nervous system govern class IV semaphorin, CD100/Sema4D and Sema4A activity in immune responses. This review provides an overview of the currently emerging immunoregulatory functions of "Immuno-semaphorins."
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