Dynamics of endosomal sorting

The endocytic pathway receives cargo from the cell surface via endocytosis, biosynthetic cargo from the late Golgi complex, and various molecules from the cytoplasm via autophagy. This review focuses on the dynamics of the endocytic pathway in relationship to these processes and covers new information about the sorting events and molecular complexes involved. The following areas are discussed: dynamics at the plasma membrane, sorting within early endosomes and recycling to the cell surface, the role of the cytoskeleton, transport to late endosomes and sorting into multivesicular bodies, anterograde and retrograde Golgi transport, as well as the autophagic pathway.