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Related Experiment Videos

Doxycycline-induced photo-onycholysis.

Lisa A Carroll1, Anne E Laumann

  • 1Section of Dermatology, Department of Medicine, University of Chicago Hospitals, Chicago, Illinois 60637-1470, USA. laecarroll@hotmail.com

Journal of Drugs in Dermatology : JDD
|January 9, 2004
PubMed
Summary

Photo-onycholysis, a rare drug reaction, causes nail separation. This case highlights doxycycline as a potential trigger for this phototoxic effect in acne patients.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Photo-onycholysis is an uncommon phototoxic reaction.
  • It involves distal nail separation from the nail bed.
  • Causes include medications or idiopathic factors.

Observation:

  • A patient with acne vulgaris developed photo-onycholysis.
  • The patient was undergoing treatment with doxycycline.

Findings:

  • Doxycycline, a common antibiotic for acne, can induce photo-onycholysis.
  • This suggests a potential phototoxic mechanism linked to doxycycline therapy.

Implications:

  • Clinicians should consider doxycycline-induced photo-onycholysis in patients presenting with nail changes.
  • Awareness of this adverse effect is crucial for managing acne patients on doxycycline.
  • Further investigation into the phototoxic potential of doxycycline is warranted.

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