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Related Experiment Videos

Polypoidal choroidal vasculopathy.

Antonio P Ciardella1, Irene M Donsoff, Sheau J Huang

  • 1The LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021, USA.

Survey of Ophthalmology
|January 9, 2004
PubMed
Summary
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Polypoidal choroidal vasculopathy (PCV) is a macular disorder causing recurrent bleeding. Advanced imaging aids understanding of this distinct condition, which affects various ethnicities and may respond to photodynamic therapy.

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Medical Imaging

Background:

  • Polypoidal choroidal vasculopathy (PCV) initially described as a hemorrhagic macular disorder.
  • Characterized by recurrent subretinal and RPE bleeding, predominantly in middle-aged Black women.
  • Pathophysiology increasingly understood through indocyanine green angiography and optical coherence tomography.

Purpose of the Study:

  • To elucidate the pathophysiology and clinical characteristics of polypoidal choroidal vasculopathy.
  • To highlight the diagnostic advancements in studying PCV.
  • To discuss the racial predilection and broader ethnic prevalence of PCV.

Main Methods:

  • Utilized indocyanine green angiography (ICGA) for detailed vascular imaging.
  • Employed optical coherence tomography (OCT) for cross-sectional retinal visualization.

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  • Clinical observation of disease course and treatment outcomes.

    • Main Results:

    • Identified characteristic inner choroidal vascular network with aneurysmal bulges (polypoidal lesions).
    • Recognized higher risk in individuals of African-American and Asian descent, but also found in Caucasian, Irish, French, German, and Italian patients (8-13% of exudative AMD).
    • Observed a remitting-relapsing course with recurrent RPE detachments, often preserving good vision long-term.

    Conclusions:

    • Polypoidal choroidal vasculopathy is a distinct clinical entity.
    • Differentiates from typical age-related macular degeneration (AMD) and other choroidal neovascularization.
    • Photodynamic therapy shows promise as a treatment alternative.