Dendritic cells and cutaneous immune responses to chemical allergens

This article reviews the role of epidermal Langerhans cells (LC) in the development of cutaneous immune responses to chemical allergens. Following topical exposure to sensitizing chemicals, LC, many of which bear allergen, are induced to migrate from the skin, via the afferent lymphatics, to the draining lymph nodes. The phenotypic and functional changes to which LC are subject during this process and their development into active immunostimulatory cells closely resembling lymphoid dendritic cells is discussed. The migration and maturation of LC following skin sensitization is of critical importance to the effective presentation of chemical allergens to T lymphocytes and the induction of allergic responses. Evidence is reviewed which suggests that these events are initiated and regulated by epidermal cytokines. The conclusion drawn is that an early event during the induction of skin sensitization is the production by keratinocytes of cytokines which stimulate the migration of LC from the skin and which also result in the functional maturation of LC into potent antigen-presenting cells.