Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exhaled nitric oxide in chronically ventilated preterm infants.

O Williams1, R Y Bhat, P Cheeseman

  • 1Children Nationwide Regional Neonatal Intensive Care Centre, 4th floor Ruskin Wing, King's College Hospital, London SE5 9RS, UK.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|January 9, 2004
PubMed
Summary

Dexamethasone treatment reduced exhaled nitric oxide (eNO) levels and oxygen requirements in ventilated preterm infants. This suggests a potential role for corticosteroids in managing respiratory support needs in this vulnerable population.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Undetected Respiratory Depression in People with Opioid Use Disorder.

Drug and alcohol dependence·2022
Same author

Non-invasive carbon dioxide monitoring in the UK: a survey of practice within neonatal intensive care.

Anaesthesia·2021
Same author

Measurement of neural respiratory drive via parasternal intercostal electromyography in healthy adult subjects.

Physiological measurement·2016
Same author

Review finds insufficient evidence to support the routine use of heated, humidified high-flow nasal cannula use in neonates.

Acta paediatrica (Oslo, Norway : 1992)·2014
Same author

Airways obstruction and pulmonary capillary blood volume in children with sickle cell disease.

Pediatric pulmonology·2013
Same author

Predictors of neonatal morbidity in fetuses with severe isolated congenital diaphragmatic hernia undergoing fetoscopic tracheal occlusion.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2013

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Biomedical Engineering

Background:

  • Premature infants often require mechanical ventilation and supplemental oxygen.
  • Elevated exhaled nitric oxide (eNO) is associated with airway inflammation in neonates.
  • Dexamethasone is a corticosteroid with anti-inflammatory properties.

Purpose of the Study:

  • To investigate the effect of dexamethasone on exhaled nitric oxide (eNO) levels in ventilated preterm infants.
  • To assess changes in oxygen requirements following dexamethasone administration.

Main Methods:

  • Measurements of exhaled nitric oxide (eNO) were taken in eight ventilated infants before and after a three-day course of dexamethasone.
  • Infant characteristics including gestational age and postnatal age were recorded.

Related Experiment Videos

  • Supplementary oxygen levels were monitored throughout the study period.

    • Main Results:

    • A statistically significant decrease in mean eNO levels was observed, from 6.5 to 4.2 parts per billion (p = 0.031).
    • Mean supplementary oxygen requirements also significantly decreased from 62% to 45% (p = 0.0078).
    • The study included infants with a mean gestational age of 25.8 weeks.

    Conclusions:

    • Dexamethasone treatment effectively reduced exhaled nitric oxide (eNO) levels in ventilated preterm infants.
    • The findings suggest that dexamethasone may help decrease the need for supplemental oxygen in this population.
    • Further research is warranted to explore the long-term benefits and optimal use of corticosteroids in neonatal respiratory care.