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GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
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GABA modulates presynaptic signalling mediated by dinucleotides on rat synaptic terminals

R Gómez-Villafuertes1, J Pintor, J Gualix

  • 1Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.

The Journal of Pharmacology and Experimental Therapeutics
|January 9, 2004
PubMed
Summary

Presynaptic GABA(B) receptor activation enhances diadenosine pentaphosphate (Ap(5)A) signaling in rat midbrain terminals. This modulation involves changes in Ap(5)A affinity and calcium responses, with PKA activity playing a key role.

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