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Vaccine-induced CD8+ T cells eliminate tumors by a two-staged attack

Dariusz W Kowalczyk1, Anthony P Wlazlo, Wynetta Giles-Davis

  • 1Department of Cancer Immunology, Greatpoland Cancer Center, Garbary 15, 61-866 Poznan, Poland.

Cancer Gene Therapy
|January 9, 2004
PubMed

Data presented here demonstrate that vaccine-induced CD8(+) T cells can eliminate their specific tumor-target with a two-staged attack. First, they release interferon-gamma that results in growth arrest of the tumor cells via induction of antiangiogenic mediators. Then, during the latter stages of the immune response, CD8(+) effector T cells eradicate the remaining tumor cells through perforin-mediated lysis. A combination of these two mechanisms is highly effective in the described model, while either pathway alone fails to completely achieve tumor rejection.

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