Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carcinoid case presentation and discussion: the American perspective.

R R P Warner1

  • 1Department of Medicine, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA. rwarner-md@carcinoid.org

Endocrine-Related Cancer
|January 10, 2004
PubMed
Summary

Aggressive, multi-modal treatment, including surgery and chemotherapy, successfully managed advanced carcinoid syndrome with liver metastases and heart complications in one patient. This approach highlights effective sequential therapy for complex carcinoid cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serotonin and gastrointestinal tract function.

Journal of the Mount Sinai Hospital, New York·1959
Same author

Carcinoid syndrome produced by metastasizing bronchial adenoma.

The American journal of medicine·1958
Same author

Situs inversus of gastrointestinal tract; complication by partial high intestinal obstruction.

United States Armed Forces medical journal·1956
See all related articles

Area of Science:

  • Oncology
  • Gastroenterology
  • Cardiology

Background:

  • Carcinoid syndrome, often associated with midgut carcinoid tumors, can lead to significant complications including liver metastases and cardiac valve disease.
  • Traditional treatments like octreotide and interferon may become insufficient as the tumor progresses.

Observation:

  • A middle-aged male patient with advanced carcinoid syndrome presented with massive liver metastases, severe cardiac valve disease, ascites, and malnutrition.
  • Despite initial supportive and biotherapy, the patient's condition deteriorated, necessitating a more aggressive treatment strategy.

Findings:

  • A sequential multi-modal therapy was implemented, including cardiac valve replacement, hepatic artery chemoembolus (HACE) injection, surgical debulking, radiofrequency ablation of liver metastases, and targeted chemotherapy (docetaxel).

Related Experiment Videos

  • The patient demonstrated an excellent response to this aggressive, integrated treatment regimen.

    • Implications:

    • This case demonstrates the potential efficacy of aggressive, sequential multi-modal therapy in managing advanced carcinoid syndrome with complex comorbidities.
    • Personalized treatment, guided by in vitro drug resistance testing, can optimize therapeutic outcomes in challenging carcinoid cases.