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Increased plasma levels of thioredoxin in patients with coronary spastic angina

Shinzo Miyamoto, Hiroaki Kawano, Tomohiro Sakamoto

    Antioxidants & Redox Signaling
    |January 10, 2004
    PubMed

    Insights

    Plasma thioredoxin levels are significantly higher in patients with coronary artery spasm, indicating it is a risk factor. Increased thioredoxin is linked to more frequent angina attacks, suggesting a role in disease activity.

    Area of Science:

    • Cardiology
    • Biochemistry
    • Internal Medicine

    Background:

    • Coronary artery spasm, a condition causing chest pain, requires better diagnostic markers.
    • Thioredoxin is a protein with known roles in oxidative stress and inflammation.

    Purpose of the Study:

    • To investigate the association between plasma thioredoxin levels and coronary artery spasm.
    • To identify thioredoxin as a potential biomarker for coronary artery spasm.

    Main Methods:

    • Plasma thioredoxin levels were measured in 170 patients undergoing coronary arteriography.
    • Patients were categorized into coronary spastic angina (n=84) and chest pain syndrome (n=86) groups.
    • Statistical analyses, including multiple logistic regression, were performed.

    Main Results:

    • Plasma thioredoxin levels were significantly higher in the coronary spastic angina group compared to the chest pain syndrome group (40.7 ± 4.1 vs. 18.2 ± 1.1 ng/ml, p<0.0001).
    • Elevated thioredoxin levels correlated with increased angina attack frequency (p=0.0004).
    • Higher plasma thioredoxin (RR 14.8) and current smoking (RR 3.39) were independent risk factors for coronary spasm.

    Conclusions:

    • Plasma thioredoxin levels are elevated in patients with coronary artery spasm.
    • Thioredoxin may serve as a valuable biomarker for diagnosing and assessing the activity of coronary artery spasm.
    • Both plasma thioredoxin and smoking are independent risk factors for coronary artery spasm.

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