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Ampicillin micronization by supercritical assisted atomization.

E Reverchon1, G Della Porta, A Spada

  • 1Università di Salerno, Dipartimento di Ingegneria Chimica ed Alimentare, Via Ponte don Melillo, 84084 Fisciano (SA), Italy. ereverchon@unisa.it

The Journal of Pharmacy and Pharmacology
|January 10, 2004
PubMed
Summary
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Supercritical assisted atomization (SAA) successfully produced ampicillin microparticles for aerosol delivery. This technique allows precise control over particle size, crucial for effective drug administration.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Chemical Engineering

Background:

  • Aerosol drug delivery requires precise control over microparticle size.
  • Supercritical fluid technology offers novel methods for particle engineering.

Purpose of the Study:

  • To produce ampicillin microparticles suitable for aerosol delivery using supercritical assisted atomization (SAA).
  • To investigate the influence of SAA process parameters on microparticle characteristics.

Main Methods:

  • Supercritical assisted atomization (SAA) utilizing supercritical CO2 and liquid solutions.
  • Systematic variation of SAA parameters: solvent type, flow rates, solute concentration, and nozzle diameter.
  • Analysis of microparticle morphology, particle size, and particle size distribution.

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Main Results:

  • Ampicillin microparticles in the 1-5 micrometer range were successfully produced using buffered water.
  • Particle size tailoring was achieved by adjusting solute concentration, yielding particles in the 1-3 micrometer range.
  • SAA demonstrated effective control over particle size distribution for aerosol applications.

Conclusions:

  • Supercritical assisted atomization is a viable technique for producing ampicillin microparticles for aerosol drug delivery.
  • SAA enables precise control over particle size and distribution, optimizing them for inhalation.
  • This study highlights the potential of SAA for tailored microparticle engineering in pharmaceutical applications.