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Updated: Aug 29, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
Published on: January 26, 2015
Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax
B A Umarova1, G N Kopylova, E A Smirnova
1Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University.
Abstract:
Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.
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