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Vitamin D intoxication and hypercalcaemia in an infant treated with pamidronate infusions

Fatih Suheyl Ezgu1, Necla Buyan, Mehmet Gündüz

  • 1Gazi University Faculty of Medicine, Department of Paediatrics, 10th Floor, Besevler, Ankara, Turkey. fatihezgu@isbank.net.tr

European Journal of Pediatrics
|January 10, 2004
PubMed

Insights

Intravenous pamidronate effectively treated hypercalcaemia caused by vitamin D intoxication in a 3-month-old infant. This bisphosphonate offers a safe and viable option for managing pediatric hypercalcemia resistant to other therapies.

Area of Science:

  • Pediatric Endocrinology
  • Pharmacology
  • Nephrology

Background:

  • Hypercalcemia in infants can stem from various causes, including vitamin D intoxication.
  • Bisphosphonates are established treatments for hypercalcemia, particularly in pediatric oncology.
  • Management of severe hypercalcemia often requires a multi-faceted approach.

Observation:

  • A 3-month-old infant presented with hypercalcemia secondary to vitamin D intoxication.
  • Intravenous pamidronate was administered to address the elevated serum calcium levels.
  • The infant's condition was monitored for efficacy and potential adverse effects.

Findings:

  • Intravenous pamidronate successfully normalized serum calcium levels in the infant.
  • Treatment with pamidronate was well-tolerated, with no observed complications.
  • This case highlights pamidronate's efficacy in a non-malignant pediatric hypercalcemia context.

Implications:

  • Pamidronate is a potential therapeutic option for pediatric hypercalcemia due to vitamin D intoxication.
  • This approach may be particularly valuable in cases resistant to standard treatments like hydration, diuretics, or corticosteroids.
  • Further research could explore the long-term outcomes and optimal dosing of pamidronate in similar pediatric cases.
Abstract

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