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Helicobacter pylori and TT virus prevalence in Japanese children

Seiichi Kato1, Hiroaki Okamoto, Yoshikazu Nishino

  • 1Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574 Sendai, Japan.

Journal of Gastroenterology
|January 10, 2004
PubMed
Abstract

Insights

Japanese children commonly acquire Helicobacter pylori and TT virus, but their transmission routes appear independent. This study investigated the prevalence and potential common transmission of these two microbes in children.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • The primary transmission route for Helicobacter pylori (oral-oral or fecal-oral) is not definitively established.
  • TT virus (TTV), a prevalent microbe in healthy individuals, is thought to spread primarily through nonparenteral routes.

Purpose of the Study:

  • To investigate the hypothesis that Helicobacter pylori and TT virus share a common transmission mode.
  • To determine the seroprevalence and transmission patterns of H. pylori and TTV in Japanese children.

Main Methods:

  • A cross-sectional study of 454 healthy Japanese children (birth to 15 years) across five geographic areas.
  • H. pylori infection determined by specific serum IgG and IgA antibodies via enzyme immunoassays.
  • TTV DNA detection and quantification using semiquantitative polymerase chain reaction.

Main Results:

  • Overall prevalences were 12.2% for H. pylori and 21.6% for TTV.
  • H. pylori prevalence increased with age (P < 0.001), while TTV prevalence did not (P = 0.23).
  • TTV DNA titers decreased with age (P = 0.02), and TTV prevalence showed significant geographic variation (P < 0.001). No correlation was found between H. pylori and TTV prevalence (P = 0.66).

Conclusions:

  • Japanese children frequently acquire both H. pylori and TTV, particularly in early childhood.
  • The acquisition of H. pylori and TTV in this cohort appears to be independent events.

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