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Schizophrenia-like behavioral changes after partial hippocampal kindling.

Jingyi Ma¹, L Stan Leung

¹Department of Physiology and Pharmacology, The University of Western Ontario, Rhichmond, London, Ontario, Canada N6A 5A5. jma2@uwo.ca

|January 13, 2004

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Repeated hippocampal seizures in rats induced behavioral changes and impaired sensorimotor gating. These effects, linked to increased dopamine activity, may mirror psychiatric symptoms in human epilepsy.

Area of Science:

Neuroscience
Behavioral Neuroscience
Epilepsy Research

Background:

Hippocampal kindling is a model for studying epilepsy.
Electrographic seizures can induce long-lasting brain changes and behavioral alterations.

Purpose of the Study:

To investigate the behavioral consequences of hippocampal kindling in rats.
To determine if the number of electrographic seizures influences behavioral changes and sensorimotor gating.

Main Methods:

Rats underwent 10 or 21 hippocampal afterdischarges (ADs) or electrographic seizures.
Behavioral tests included open field, Porsolt forced swimming, and prepulse inhibition of acoustic startle.
Locomotor activity was assessed with and without methamphetamine administration.

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Main Results:

21 ADs, but not 10, decreased social contact and increased isolation, climbing, and chasing behaviors.
A deficit in sensorimotor gating and increased methamphetamine-induced locomotor activity were observed after 21 ADs.
No significant differences in spontaneous locomotor activity or forced swimming were found.

Conclusions:

Repeated hippocampal electrographic seizures can induce significant behavioral alterations and sensorimotor gating deficits.
These changes may be mediated by enhanced dopaminergic functions.
Findings suggest a potential link between hippocampal seizures, dopamine, and psychiatric symptoms in epilepsy.