Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A graphical tool for parasite genome annotation.

Daniel Nilsson1, Björn Andersson

  • 1Center for Genomics and Bioinformatics, Karolinska Institutet, S-17177 Stockholm, Sweden.

Computer Methods and Programs in Biomedicine
|January 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bayesian fine-mapping pinpoints candidate genes and pleiotropic loci of production traits from a chicken backcrossing scheme.

BMC genomics·2026
Same author

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1-associated epithelial recurrent erosion dystrophy.

Acta ophthalmologica·2026
Same author

Genetically Determined Levels of Inflammation-Related Proteins and Functional Outcome After Ischemic Stroke: A Mendelian Randomization Study.

Journal of stroke·2026
Same author

Predicting post-stroke functional outcome using explainable machine learning and integrated data.

Scientific reports·2026
Same author

Drug resistant epilepsy driven by <i>RHEB</i> gene variants - Current evidence and a novel report of a paedatric case.

Epilepsy & behavior reports·2026
Same author

The genomic medicine center Karolinska 10-year report on genome sequencing for rare diseases and a strategy for stepwise clinical implementation.

Genome medicine·2026
Same journal

Facial iPPG heatmap patterns based on period-aware autoencoder show association with carotid atherosclerosis towards non-contact hemodynamic assessment.

Computer methods and programs in biomedicine·2026
Same journal

Explainable machine learning models predict liver fibrosis risk and outcome in the general population: Development and multi-cohort external validation.

Computer methods and programs in biomedicine·2026
Same journal

Evaluation of surrogate endpoints for survival outcomes using the surrogate package in R.

Computer methods and programs in biomedicine·2026
Same journal

Relative spectral and frication-based descriptors as numerical indicators of place of articulation shifts in fricatives produced by Polish children.

Computer methods and programs in biomedicine·2026
Same journal

Leaflet resection improves valve expansion and hemodynamic performance in redo TAVI with balloon- and self-expanding transcatheter heart valve configurations.

Computer methods and programs in biomedicine·2026
Same journal

Spectral super-resolution for Parkinson's voice via representation-level methods under mixed-reality acquisition.

Computer methods and programs in biomedicine·2026
See all related articles

A new graphical tool speeds up genomic sequence annotation. This software aids in importing, analyzing, and exporting genetic data, enhancing genome project efficiency for protozoa and prokaryotes.

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Genomic sequence annotation is crucial for understanding gene function.
  • Manual annotation is time-consuming and complex.
  • Existing tools may lack integration or specific features.

Purpose of the Study:

  • To develop a user-friendly graphical tool for rapid primary annotation of genomic sequences.
  • To enhance the efficiency and accuracy of genome annotation processes.
  • To provide a flexible platform for both automated and manual annotation tasks.

Main Methods:

  • Development of an integrated graphical interface for sequence analysis.
  • Incorporation of feature prediction programs and similarity searches.
  • Implementation of rule-based feature corroboration and a novel decision support heuristic (ORF orientation, length, base composition).

Related Experiment Videos

Main Results:

  • The tool facilitates rapid primary annotation within a single interface.
  • It integrates sequence import, analysis, filtering, manual curation, and export functionalities.
  • The decision support heuristic improves annotation efficiency without sacrificing flexibility.

Conclusions:

  • The developed graphical tool significantly enhances the speed and efficiency of genomic sequence annotation.
  • It is particularly beneficial for protozoan parasite genome projects and applicable to prokaryotic annotation.
  • The tool is actively used in the Trypanosoma cruzi genome project and available upon request.