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Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
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Effect of abciximab on prothrombin activation and thrombin generation in patients with acute myocardial infarction

Piera Angelica Merlini1, Alessandra Repetto, Anna Maria Andreoli

  • 1Division of Cardiology, Ospedale Niguarda, Milan, Italy. ARDIS001@planet.it

The American Journal of Cardiology
|January 13, 2004
PubMed

Fibrinolysis in acute myocardial infarction activates blood coagulation and may favor reocclusion or ischemic complications. The aim of the GUSTO V Italian Hematologic Substudy was to compare the effects of full-dose reteplase on coagulation activation markers with those of half-dose reteplase combined with full-dose abciximab, a platelet glycoprotein IIb/IIIa receptor antagonist, during the early phase after acute myocardial infarction.

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