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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
Reduced COMT activity as a possible environmental risk factor for breast cancer. Opinion
1Laboratory of Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20814-4008, USA. CrevelingB@extra.niddk.nih.gov
Neurotoxicity Research
|January 13, 2004
Abstract:
Recent genetic epidemiological studies implicate a low activity form of catechol-O-methyltransferase (COMT) with increased risk factor for breast cancer. Taking into account, the role of COMT in the metabolism of otherwise carcinogenic catecholestrogens, it is reasonable to propose that environmental or dietary products that inhibit COMT pose a risk for breast cancer.
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