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Cystic fibrosis in adults: current and future management strategies

Brian M Morrissey1, Bettina C Schock, Gregory P Marelich

  • 1Adult Cystic Fibrosis Clinic and University of California Davis School of Medicine, Sacramento, CA, USA. bmmorrissey@ucdavis.edu

Clinical Reviews in Allergy & Immunology
|January 13, 2004
PubMed

Insights

Cystic Fibrosis (CF) affects over 30,000 Americans, remaining life-limiting despite advances. This review covers CF respiratory issues, management, and future therapies for improved patient outcomes.

Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Pediatrics

Background:

  • Cystic Fibrosis (CF) impacts over 30,000 individuals in the US.
  • Despite advancements, CF remains a significant life-limiting illness.
  • Early recognition is increasing due to newborn screening, genetic testing, and awareness.

Purpose of the Study:

  • To review the pathophysiology, diagnosis, and management of respiratory manifestations in CF.
  • To summarize current and future therapeutic strategies for CF patients.

Main Methods:

  • Literature review of CF pathophysiology.
  • Analysis of diagnostic approaches for CF respiratory disease.
  • Summary of current and emerging CF treatments.

Main Results:

  • Severe lung disease is the primary life-limiting pathology in CF.
  • Medical management has improved life expectancy for CF patients.
  • Newborn screening and genetic testing enhance early diagnosis.

Conclusions:

  • Respiratory complications are central to CF's life-limiting nature.
  • Ongoing research and improved therapies offer hope for better CF management.
  • Future therapies aim to further improve outcomes for individuals with CF.

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