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Stones associated renal pelvic malignancies
M Raghavendran1, A Rastogi, D Dubey
1Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow - 226 014, India.
Indian Journal of Cancer
|January 13, 2004
Summary
Renal pelvic malignancies associated with stones, particularly squamous cell carcinoma, have a poor prognosis. Early diagnosis and complete surgical excision are crucial for improving patient survival rates.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Retrospective analysis of clinico-pathological characteristics of renal pelvic malignancies linked to stones.
- Investigating the biological behavior and prognostic factors of these rare tumors.
Purpose of the Study:
- To define the biological behavior and prognostic factors for renal pelvic malignancies associated with stones.
- To highlight the importance of early diagnosis and complete surgical management.
Main Methods:
- Retrospective study of 18 cases of malignancies associated with renal stone disease.
- Classification of tumors by pathological type (squamous cell carcinoma, transitional cell carcinoma, adenocarcinoma).
- Analysis of clinical, imaging, and pathological features in relation to prognosis.
Main Results:
- High incidence of squamous cell carcinoma (SCC) (15/18 cases) with uniformly poor prognosis (median survival 3.6 months).
- Transitional cell carcinoma (TCC) and Adenocarcinoma (AC) showed better median survival (7.5 and 24 months, respectively).
- Incomplete nephrectomy led to significantly poorer survival (3.56 months) compared to radical extirpation (18 months).
- Disease stage was identified as the main prognostic factor.
Conclusions:
- Malignancies associated with stone disease present insidiously, requiring high clinical suspicion for preoperative diagnosis.
- Grave prognosis associated with incomplete excision underscores the imperative for earlier and complete diagnosis and treatment.