Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cycle length sequence dependent repolarization dynamics.

Robert L Lux1, Philip R Ershler

  • 1Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City 84112-5000, USA. lux@cvrti.utah.edu

Journal of Electrocardiology
|January 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antiarrhythmic Mechanisms of Epidural Blockade After Myocardial Infarction.

Circulation research·2024
Same author

Thoracic epidural blockade after myocardial infarction benefits from anti-arrhythmic pathways mediated in part by parasympathetic modulation.

bioRxiv : the preprint server for biology·2024
Same author

The derivative of tissue activation as a marker of arrhythmogenic myocardium.

Heart rhythm·2022
Same author

Proarrhythmic Effects of Sympathetic Activation Are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts.

JACC. Clinical electrophysiology·2022
Same author

Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas.

Circulation research·2021
Same author

Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant.

Journal of the American College of Cardiology·2018

Understanding dynamic changes in cardiac repolarization is key to predicting arrhythmias. This study tracks repolarization changes in canine hearts, offering new insights into arrhythmia risk assessment and patient monitoring.

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Electrophysiology

Background:

  • Cardiac repolarization heterogeneity and restitution influence arrhythmogenesis.
  • Current assessments often lack dynamic analysis of repolarization changes.

Purpose of the Study:

  • To investigate global repolarization dynamics in response to programmed cycle length changes.
  • To explore the potential of dynamic repolarization assessment for arrhythmia risk stratification.

Main Methods:

  • Tracking beat-to-beat repolarization in canine hearts.
  • Applying rapid (step), linear (sawtooth), and random cycle length sequences.

Main Results:

  • Demonstrated global repolarization changes in response to dynamic cycle length variations.

Related Experiment Videos

  • Characterized beat-to-beat repolarization tracking under different pacing protocols.

    • Conclusions:

    • Dynamic repolarization characterization may enhance arrhythmia substrate identification.
    • This approach could improve risk assessment and patient monitoring during electrophysiology testing and therapy.