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Related Experiment Videos

Managing and analysing data from a large-scale study on Framingham Offspring relating brain structure to cognitive

Joseph M Massaro1, Ralph B D'Agostino, Lisa M Sullivan

  • 1Department of Biostatistics, Boston University School of Public Health, 715 Albany Street T3E, Boston, MA 02118, USA. jmm@bu.edu

Statistics in Medicine
|January 13, 2004
PubMed
Summary

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Researchers are collecting brain structure and cognitive data from the Framingham Offspring cohort to study normative aging and cognitive decline. This large dataset will help understand brain changes over time.

Area of Science:

  • Neuroscience
  • Gerontology
  • Biostatistics

Background:

  • The Framingham Heart Study is collecting brain structure and cognitive data from the Framingham Offspring cohort.
  • This initiative is funded by the National Institute on Aging (NIA) to create a large dataset for studying aging and cognitive decline.

Purpose of the Study:

  • To establish one of the largest datasets assessing brain structure changes related to normative aging.
  • To analyze cognitive function changes in relation to brain structure over time.
  • To describe the collaborative effort involved in data collection and analysis.

Main Methods:

  • Recruitment of participants from the Framingham Offspring study.
  • Collection of brain structure and cognitive function data.

Related Experiment Videos

  • Data management and statistical analysis of collected information.

    • Main Results:

    • Ongoing analysis of data collected up to 2002.
    • Identification of statistical challenges in relating brain structure to cognitive function.

    Conclusions:

    • The Framingham Offspring study is creating a valuable resource for aging research.
    • Further analysis is needed to fully understand the relationship between brain structure and cognitive function in aging individuals.