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Related Experiment Videos

Trials in surgery.

R Lilford1, D Braunholtz, J Harris

  • 1Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. r.j.lilford@bham.ac.uk

The British Journal of Surgery
|January 13, 2004
PubMed
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This study addresses challenges in surgical trials, introducing innovative methods like the tracker trial concept. It highlights the ongoing evolution of surgical research methodologies for better evaluation.

Area of Science:

  • Surgical Research Methodology
  • Clinical Trial Design

Background:

  • Surgical trials present unique methodological challenges.
  • This paper reviews 10 years of research from the UK National Health Service Research and Development programme.

Purpose of the Study:

  • To examine and propose solutions for common problems in surgical clinical trials.
  • To discuss methodological developments and their impact on evaluating surgical procedures.

Main Methods:

  • Consideration of issues such as blinding, surgeon skill dependence, and technological advancements.
  • Review of methodological research sponsored by a national health program.

Main Results:

  • Introduction of the tracker trial concept for adaptive trial design.

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  • Discussion of trial governance, ethical considerations, and the role of databases.

    • Conclusions:

    • The methodology for evaluating surgical procedures is continually advancing.
    • Statistical and scientific principles allow for creative surgical trial designs.